Students

a b c d e f g h i j k l m n o p q r s t u v w x y z All
(Includes Name, Title, Research Interests)
Mentor:
Alan Boyle
Year:
2016
Undergraduate Institution:
University of Washington
Honors:
Dept. Honors in Molecular Cellular and Developmental Biology
Service:
AWIS, FEMMES, GUMB, Student Councils, March for Science, Michigan Science Center, Forsythe Middle School Science Fair
Mentor:
Sriram Venneti
Year:
2015
Undergraduate Institution:
University of Texas at El Paso
Honors:
Magna cum Laude (B.Sc.), Rackham Merit Fellowship
Service:
University of Michigan Society for the Advancement of Chicanos and Native Americans founding board member
Research Interests:

Studying the intersection between cancer metabolism and epigenetics in brain tumors. Specifically, we evaluate the effects of altered metabolism on histone and DNA methylation in brain tumors.

Mentor:
Linda Samuelson
Year:
2013
Undergraduate Institution:
Juniata College
Honors:
54th Midwest Society for Developmental Biology Best Poster Award (2016), CMB Merit Award (2016), HHMI International Student Research Fellowship Finalist (2016), Rackham Conference Travel Grant (2015, 2016), CMB Conference Travel Grant (2015, 2016), CMB/Medical School Fellowship (2015), Rackham Pre-Candidate Graduate Student Research Grant (2015), Rackham International Student Fellowship (2014), Benard L. Maas Fellowship (2013)
Service:
Graduate Rackham International (GRIN) Mentor (2016-Present), CMB Program Committee (2016-Present), CMB Student Advisor (2016-Present), International Center Student Council (ICSC) Representative (2016-Present), UROP Research Symposium Judge (2016), Females Excelling More In Math Engineering & Sciences (FEMMES) Capstone Group Leader (2016), AAAS Global Science Engagement Conference Session Aide In Washington, D.C. (2016), Bioartography Booth Volunteer (2015, 2016), The Michigan Science Center Steminista Role Model (2015-Present), CMB Career Development Committee (2014-Present), CMB Departmental Newsletter Committee (2014-2016), Short Term Educational Program (STEP) Mentor (2015, 2016), Leading Informed Policy with Science (LIPS) (2015-2016), Association Of Multicultural Scientists (AMS) (2013-Present), Women In Science & Engineering (2013-Present)
Teaching Experience:
Graduate Student Instructor For CDB 530 Cell Biology
Research Interests:
The role of Notch signaling in intestinal stem cell function & intestinal epithelial cell homeostasis

 

Mentor:
Kristen Verhey
Year:
2014
Undergraduate Institution:
Ohio Wesleyan University
Honors:
NSF-GRFP Fellow (2016), Precandidate Rackham Graduate Student Research Grant (2016)
Service:
UM Females Excelling More in Math, Engineering, and the Sciences (FEMMES), The Michigan Health Sciences Pre-College Exposure Academy (MHSPEA)
Teaching Experience:
Graduate Student Instructor CDB560 Quantitative Fluorescence Microscopy
Research Interests:

Utilizing a chemical-gentic approach to engineer inhibitable kinesin motor proteins s a strategy to elucidate their fundamental properties in cells

Mentor:
David Markovitz
Year:
2012
Undergraduate Institution:
Barry University
Honors:
Cellular Biotechnology Training Program (2015-2017); Cellular and Molecular Biology Training Grant; Rackham Pre-Candidate Research Grant (2014); Rackham Merit Fellow
Service:
Cellular and Molecular Biology Recruitment Committee (2017); Rackham Merit Fellow Graduate Student Advisory Council Member (2016); Cellular and Molecular Biology Recruitment Committee (2016); Cellular and Molecular Biology Social Committee (2016); Rackham Merit Fellow Graduate Student Advisory Council Member (2015)
Teaching Experience:
Teacher Assistant to DENT 525
Research Interests:

Elucidating the role of the Human Endogenous Retrovirus (HML-2) accessory protein Np9 in diverse human malignancies

Jennifer Chik
Mentor:
Uhn-Soo Cho
Year:
2013
Undergraduate Institution:
California Polytechnic State University
Honors:
Rackham Graduate Student Research Grant, NIH Cellular and Molecular Biology Training Grant T32-GM007315
Service:
CMB Symposium Committee Member, CMB Student Advisor, Volunteer at Ann Arbor Hands On Museum, FEMMES Capstone Volunteer, MHSPEA Volunteer/Instructor, BrainsRule! Volunteer, GUMB Mentor
Teaching Experience:
Graduate Student Instructor- BIOCHEM 212
Research Interests:

Structure and function of centromere and kinetochore proteins

 

Mentor:
Ann Miller
Year:
2016
Undergraduate Institution
Eastern Michigan University
Honors:
NSF Graduate Research Fellowship Recipient (2017)
Service:
Science Communication Fellowship with UM’s Museum of Natural History, Females Excelling More in Math, Engineering, and Science (FEMMES), Lean in for Graduate Students, Association for Women in Science, CMB Career Committee.
Research Interest:
Using optogenetics, investigate the spatiotemporal regulation of small GTPase RhoA and how it orchestrates actin cytoskeletal dynamics responsible for junctional remodeling and cytokinesis in vertebrate epithelial tissues.
Mentor:
Manoj Puthenveedu
Year:
2016
Undergraduate Institution:
Penn State University
Honors:
NSF GRFP awardee, ARCS foundation Pittsburgh Chapter award recipient.
Service:
Social committee (Carnegie Mellon), Graduate sciences teaching club (Carnegie Mellon)
Research Interests:
I study the biosynthetic trafficking of G-protein-coupled receptors (GPCRs). GPCR localization to the the cell surface is critical for functional coupling to both extracellular agonists and G-protein effectors on the plasma membrane. Despite the functional importance of GPCR localization to the plasma membrane, relatively little is known about the biosynthetic trafficking of these receptors to the cell surface. I would like to understand how the trafficking of these receptors to the cell surface is regulated and how we can target receptors to the surface to increase signaling.
Research Interests:

I study the biosynthetic trafficking of G-protein-coupled receptors (GPCRs). GPCR localization to the the cell surface is critical for functional coupling to both extracellular agonists and G-protein effectors on the plasma membrane. Despite the functional importance of GPCR localization to the plasma membrane, relatively little is known about the biosynthetic trafficking of these receptors to the cell surface. I would like to understand how the trafficking of these receptors to the cell surface is regulated and how we can target receptors to the surface to increase signaling.

Mentor:
Billy Tsai
Year:
2013
Undergraduate Institution:
Westminster College
Honors:
CMB Training Grant, Rackham Travel Grant, Poster Presentation at FASEB “From misfolded proteins in the ER to Disease”.
Service:
CMB Career Development Committee (2014-2015), CMB Fall 2015 Short Course Committee (2014-2015), CMB Social Committee (2014-present)
Teaching Experience:
GSI for CDB 530 (Cell Biology) 2015
Research Interests:
ER-associated degradation of mutant proinsulins

 

Mentor:
Allen Liu
Year:
2014
Undergraduate Institution:
SUNY Fredonia
Honors:
NSF Graduate Research Fellowship, University of Michigan Maas Fellowship, Rackham Pre-Candidate Research Grant, University of Michigan Library Mini-Grant
Research Interests:

I am interested in developing spatial and temporally resolved proteomic techniques to study clathrin-mediated endocytosis.

Mentor:
Yatrik Shah
Year:
2015
Undergraduate Institution:
Ohio State University
Honors:
Shapiro/ Malik/ Forrest Award, Rackham Pre-Candidate Research Grant
Service:
PIBS 2015 Social Committee, Big Brothers Big Sisters of Washtenaw County, Lean In for Graduate Students, CMB Career Committee
Research Interests:

Studying the role of the immune system in colon cancer development.

Mentor:
Yukiko Yamashita
Year:
2014
Undergraduate Institution:
Rochester Institute Of Technology
Honors:
CMB Training Grant T32-GM007315, Honorable mention on the NSF Graduate Research Fellowship Program
Research Interests:

Asymmetric stem cell division and nonrandom sister chromatid segregation in Drosophila melanogaster

Anabel Flores
Mentor:
Christin Carter-Su
Year:
2013
Undergraduate Institution:
California Baptist University
Honors:
Howard Hughes Gilliam Fellowship for Advanced Study, 2016; Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31), 2016 (declined); AGEP (Alliance for Graduate Education and the Professoriate) research award, 2015 Rackham Pre-Candidate Research Grant, 2015; Rackham Conference Travel Grant, 2015; Gordon Research Conference Carl Storm Underrepresented Minority Fellowship, 2015; Systems of Integrative Biology Training Grant, 2014-2016; Rackham Merit Fellowship, University of Michigan, 2013-Present
Service:
CMB Recruitment Committee (2017), CMB Retreat committee (2017), HHMI Gilliam Fellowship Planning Committee (2017-2018) applied; Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) Event Coordinator (2016- present); Cellular and Molecular Biology Recruitment Committee (2016); AGEP (Alliance for Graduate Education and the Professoriate) Community Advisory Board member, (2015-2016); University of Michigan Volunteer Corps (2014-2015); Biotechnology Program, (March 2016- present); Michigan Health Sciences Pre-College Exposure Academy (MHSPEA), 2016
Teaching Experience:
Biotechnology Program for High School Students
Research Interests:
Use of the human obesity-associated P322S mutation in SH2B1 to gain insight into critical neuronal functions of SH2B1 pertinent to the regulation of body weight 

 

Brittany Flores
Mentor:
Sami Barmada
Year:
2013
Undergraduate Institution:
Indiana University
Honors:
2015 & 2014 Rackham Conference Travel Grant, 2015 Poster Presentation Award - Honorable Mention, 35th Annual Cellular & Molecular Biology Symposium, 2014 & 2015 NIH Cellular and Molecular Biology Training Grant
Service:
CMB retreat committee (present), CMB recruitment committee (2016), AMS Operations Manager (present), AMS Social Chair (2014-2015), BrainsRule! Demonstration Leader (2015-2016)
Teaching Experience:
Graduate Student Instructor for Biochemistry 212 Descriptive Biochemistry (Fall 2016)
Research Interests:

Mechanisms of Neurodegeneration in C9orf72-linked ALS and FTD

Mentor:
Scott Soleimanpour
Year:
2016
Undergraduate Institution:
Western Washington University Honors College
Service:
Ann Arbor Hands-On Museum, Michigan Health Sciences Pre Exposure Academy, UROP mentoring
Research Interests:
I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
Research Interests:

I work in a beta-cell biology and diabetes lab.  We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.

Year:
2016
Undergraduate Institution:
Tufts University
Mentor:
Kathy Spindler
Year:
2013
Undergraduate Institution:
Hope College
Honors:
Rackham Student Research Grant, NSF Graduate Research Fellowship Program Honorable Mention, Barry M. Goldwater Scholarship Honorable Mention, Rackham Travel Grant, Poster Presentation at the American Society for Virology Annual Meeting 2015; Poster presentation at the International Adenovirus Meeting in Barsinghausen, Germany
Service:
Participated in FEMMES (Females Excelling More in Math, Engineering and the Sciences)
Research Interests:
Molecular pathogenesis of encephalitic virus infections

 

Mentor:
Anthony Antonellis
Year:
2013
Undergraduate Institution:
Visvesvarya Technological University
Graduate Institution (Master's Program):
University at Albany, SUNY
Honors:
Cellular and Molecular Biology Fellowship (2015-2016 & 2014-2015), Rackham Pre-candidate Research Grant 2014, Rackham Conference Travel Award 2015
Service:
Co-founder CMB Career Committee
Teaching Experience:
Graduate Student Instructor - PHYSIOL 576
Research Interests:
Transcriptional regulation of genes important for nervous system development and function

 

Mentor:
Mark Chiang
Year:
2015
Undergraduate Institution:
University of Illinois at Urbana Champaign
Honors:
Rackham Graduate Student Research Grant, CMB T-32 training grant awardee (2016-2017), Rackham Pre-Candidate Graduate Student Research Grant
Undergraduate Awards:
Undergraduate Awards: University of Illinois Chancellor’s Honors Program, University of Illinois LAS James Scholar, University of Illinois Roger’s Scholar, Molecular and Cellular Biology Honors Concentration, National Merit Scholarship Awardee
Service:
Teen Advisory Council for Patient and Family Centered Care (UM Mott Children’s Hospital), Teen Night Coordinator for UM Mott Children’s Hospital, Teen Advisory Council coordinator for Mott Children's Hospital, Teen Night coordinator for Mott Children's Hospital, MSTP Program Activities Committee Member
Teaching Experience:
Kaplan Test Prep MCAT Instructor and Tutor 2011-2013
Research Interests:

I am studying factors that may be regulating selective oncogenic Notch1 signaling in T-cell Acute Lymphoblastic Leukemia, using biochemical and in vivo studies. 

Mentor:
Peter Todd
Year:
2014
Undergraduate Institution:
Yale University
Honors:
Kirschstein NRSA Individual Predoctoral Fellowship-F31 (2017), NIH Cellular and Molecular Biology Training Grant-T32 (2015, 2016), Rackham Predoctoral Graduate Student Research Grant (2016), Rackham Conference Travel Grant (2015, 2016), Oral Presentation Award - Rustbelt RNA Meeting (2016)
Service:
CMB Short Course Committee (Fall 2016), CMB Social Committee (Fall 2016), Females Excelling More in Math Engineering & Sciences Capstone Group Leader, Michigan Health Sciences Pre-College Exposure Academy Lab Instructor
Research Interests:

Elucidating the mechanism of RAN translation in neurodegenerative diseases

Mentor:
Jordan Shavit
Year:
2015
Undergraduate Institution:
Kalamazoo College
Service:
Galens Medical Society, University of Michigan Student Run Free Clinic
Research Interests:

Uncovering and characterizing novel chemical and genetic modifiers of the coagulation cascade

Mentor:
Mara Duncan
Year:
2014
Undergraduate Institution:
CUNY Queens College
Honors:
NSF GRFP Honorable Mention
Service:
CMB Career Committee, FEMMES (Females Excelling More in Math, Engineering, and Science), MSPHEA
Research Interests:

Characterization of the evolutionary conserved E3 ubiquitin ligase complex, the GID Complex, and its role in membrane trafficking of plasma membrane proteins during glucose starvation. 

 

Mentor:
David Ginsburg
Year:
2014
Undergraduate Institution:
The Ohio State University
Research Interests:
Genetic control of virulence genes in invasive streptococci

 

Mentor:
Nils Walter
Year:
2015
Undergraduate Institution:
SASTRA University, India
Honors:
Bernard Maas Fellowship (2015)
Service:
PIBS preview weekend host, CMB recruitment weekend assistance
Research Interests:

Uncovering biophysical rules governing non-coding RNA mediated regulation of translation, focusing on miRNA degradation pathways

Mentor:
William Dauer
Year:
2016
Undergraduate Institution:
Massachusetts Institute of Technology
Service:
Activities Facilitator at the Ann Arbor Hands-On Museum; Flint water distribution volunteer; TA for ‘lab on wheels’ biotechnology class for 9th grade students; Volunteer judge at Forsythe middle school science fair; PIBS 2016 social committee; CMB Career committee; DEI Career development committee.
Research Interest:
Studying the mechanism of nuclear pore complex formation in neurons and the role of torsinA with regards to nuclear pore biology.
Research Interests:

Studying the mechanism of nuclear pore complex formation in neurons and the role of torsinA with regards to nuclear pore biology

Mentor:
Ariella Shikanov
Year:
2016
Undergraduate Institution:
Bowdoin College
Research Interests:
Understanding the reproductive consequences of testosterone administration for transgender men using a mouse model. Using an immuno-isolating hydrogel to restore ovarian endocrine function and prevent cancer metastasis.
Mentor:
Nina Lin
Year:
2014
Undergraduate Institution:
The University of Michigan
Honors:
NSF GRFP Honorable Mention, Rackham Graduate Student Research Grant, Maas Fellowship
Service:
Volunteer for WISE,BrainsRule! Neuroscience workshop for middle schoolers, and at the Detroit Science Center with Association of Multicultural Scientists, consultant for the 2015 University of Michigan Synthetic Biology Team
Research Interests:

I am interested in synthetic biology research which investigates fundamental biological mechanisms in order to engineer innovative systems of novel function for biotechnology applications. 

Mentor:
Patrick Hu
Co-Mentors:
Patrick J. Hu M.D./Ph.D. and Scott F. Leiser, Ph.D.
Year:
2012
Undergraduate Institution:
University of Iowa
Teaching Experience:
Graduate Student Instructor CDB 530
Research Interests:

How do genes and environment interact to control longevity and healthy aging? Specifically, I am characterizing a carboxylesterase family member that promotes increased longevity in nematode models of low insulin signaling and high DAF-16/FOXO transcription factor activity. 

Mentor:
Jiandie Lin
Year:
2015
Undergraduate Institution:
The University of Michigan
Research Interests:

I study secreted factors and their effects on metabolism.

Mentor:
Manojkumar Puthenveedu
Year:
2016
Undergraduate Institution:
University of Maryland
Research Interest:
Identify and examine the homeostatic regulation of mu-opioid receptor recycling and study its regulatory signaling pathway. Study and identify the cellular molecules required for opioid receptor trafficking and signaling in response to various neuropeptides.
Research Interests:

Identify and examine the homeostatic regulation of mu-opioid receptor recycling and study its regulatory signaling pathway. Study and identify the cellular molecules required for opioid receptor trafficking and signaling in response to various neuropeptides.

Mentor:
Anthony Antonellis
Year:
2016
Service:
MSTP Ethics Committee (2017), MSTP Retreat Social Committee (2016, 2017), MSTP Retreat Snack Committee (2017), Doctors of Tomorrow Mentor (2015-2016), MiHealth Leadership Team (2016-2017), Teen Night Coordinator at Mott Children’s Hospital (2016)
Research Interest:
Molecular mechanisms of disease-associated tRNA synthetase mutations.
Mentor:
William Dauer
Year:
2016
Undergraduate Institution:
Emory University
Service:
UAAMSA Health Fair volunteer coordinator, Ophthalmology Hope Clinic volunteer
Research Interests:
Studying the role of cholinergic interneuron dysfunction in movement disorders such as Parkinson’s disease and DYT1 dystonia. These studies include behavioral and molecular experiments involve conditional knock-outs of Tor1A, the gene mutated in DYT1 dystonia, as well as knock-ins of the mutated form of Tor1A found in patients. I am also studying the roles and relationship between Tor1A and Tor1B, a neighboring and highly similar gene. These experiments involve various combinations of Tor1A and Tor1B knock-outs and will shed light on the role that Tor1B plays in compensating for Tor1A mutation and loss of function. These studies could further the understanding of the limited penetrance of DYT1 dystonia.
Research Interests:

I am pursuing my thesis in the Dauer lab. I plan to study the role of cholinergic interneuron dysfunction in movement disorders such as Parkinson’s disease and DYT1 dystonia. These studies include behavioral and molecular experiments involve conditional knock-outs of Tor1A, the gene mutated in DYT1 dystonia, as well as knock-ins of the mutated form of Tor1A found in patients. I am also studying the roles and relationship between Tor1A and Tor1B, a neighboring and highly similar gene. These experiments involve various combinations of Tor1A and Tor1B knock-outs and will shed light on the...

Mentor:
Peter Todd
Year:
2014
Undergraduate Institution:
Vassar College
Honors:
General and departmental honors in Neuroscience and Behavior from Vassar College (2010), Neuroscience and Behavior Senior Prize from Vassar (2010), Olivia M. Lammert Book Prize for Organic Chemistry from Vassar
Teaching Experience:
Co-taught an elective course in neuroscience at Community High School, Ann Arbor (2013)
Research Interests:
Mechanism and regulation of repeat-associated, non-ATG (RAN) protein translation in neurodegenerative disease

 

Mentor:
Andrew Lieberman
Year:
2016
Undergraduate Institution:
University of California, Berkeley
Research Interests:

Understanding pathogenesis of Niemann-Pick C and disruptions in protein quality control and autophagy

Mentor:
Chad Brenner
Year:
2013
Undergraduate Institution:
Hope College
Honors:
Appointed to training grant NIH T-32-GM007315 (2014-2015)
Service:
Science Olympiad Co-Coach for Slauson Middle School 2015-2016
Research Interests:
Identifying the resistance mechanisms to targeted monotherapy treatments in head and neck squamous cell carcinoma

 

Mentor:
Sue Hammoud
Year:
2016
Undergraduate Institution:
University of Washington
Research Interests:
Investigating the function of paternally-inherited histones during early embryogenesis.
Research Interests:

Investigating the function of paternally-inherited histones during early embryogenesis.

Mentor:
Stephanie Bielas
Year:
2015
Undergraduate Institution:
The University of Michigan
Service:
Alternative Spring Breaks
Research Interests:

Investigating the role of ASXL3 in Polycomb repression and characterizing the transcriptional plasticity required for neural differentiation 

Mentor:
Marina Pasca Di Magliano
Year:
2016
Research Interest:
Investigating the Role of Arginase 1 in the Pancreatic Cancer Microenvironment.
Mentor:
Sunny Wong
Year:
2013
Undergraduate Institution:
Humboldt State University
Service:
Volunteer for FEMMES capstone, member of Graduate/Undergraduate Mentorship in Biology (GUMB), volunteer soccer coach Ann Arbor Rec & Ed
Teaching Experience:
Teaching assistant for DENT 525 (Cell and Molecular Biology for D1 students) – Fall 2015
Research Interests:
Examining early events in hair follicle lumen formation

 

Mentor:
Jason Spence
Year:
2014
Undergraduate Institution:
Boston University
Honors:
Recipient of the Rackham Merit Fellowship, the NIH Cellular and Molecular Biology Training Grant, and the NIH Tissue Engineering and Regenerative Medicine Training Grant. National Science Foundation Graduate Research Fellowship, Honorable Mention
Service:
Females Exceeding More in Math, Engineering and Science (FEMMES), 2014 - present, Volunteer judge for Forsythe county middle school science fair, January 2015
Research Interests:

Alyssa is broadly interested in the cellular mechanisms governing mammalian tissue development, disease, and repair. 

Mentor:
Scott Leiser
Year:
2016
Undergraduate Institution:
University of Washington
Service:
Science Fair Judge at Forsythe Science Fair and SE Michigan Science Fair; Science advocate at the Michigan Science Center representing AMS
Teaching Experience:
TA for Biology of Aging course led by Dr. Matt Kaeberlein and Dr. Daniel Promislow –Marine Biological Laboratory (Summer 2013, 2014); TA for Conservation Biology (Winter 2013) and Comparative Physiology (Spring 2013) – University of Washington
Research Interests:

Elucidating the downstream mechanisms by which FMOs, flavin-containing monooxygenases, extend lifespan in C. elegans and mice.

Mentor:
Ray Trievel
Year:
2015
Undergraduate Institution:
Miami University
Research Interests:

Identification of novel non-histone substrates of methyltransferases as well as structural and functional characterization of KDM5 demethylases

Mentor:
Scott Pletcher
Year:
2016
Undergraduate Institution: Butler University
Butler University
Services:
FEMMES and WISE
Mentor:
Andrew Lieberman
Year:
2015
Undergraduate Institution:
University of Maryland, College Park
Honors:
Graduated Cum Laude, Phi Beta Kappa
Service:
Executive Board Member of the LRN Foundation; President (former) of the SDU Alumni Board
Teaching Experience:
Teaching Assistant in Laboratory Sessions, Johns Hopkins Mouse Phenotyping Course
Research Interests:

Examining the therapeutic potential of chaperone machinery in neurodegenerative diseases

Mentor:
Ivan Maillard
Year:
2015
Undergraduate Institution:
The University of Michigan
Honors:
Rackham Pre-candidate Grant, Poster at Stromal Cells in Immunology Keystone Symposia; Outstanding Poster: Notch Signaling Gordon Research Conference (2016); American Association of Immunologists Young Investigator Award: Autumn Immunology Conference (2016)
Service:
UM-Student Run Free Clinic – Clinical volunteer; MSTP Program Activities Committee
Research Interests:

Understanding the role of stromal cells in alloimmunity and other immune responses.

Mentor:
Margaret Westfall
Year:
2016
Undergraduate Institution:
University of Maryland, Baltimore County
Service:
Volunteer for Chinmaya Organization for Rural Development (CORD), volunteer for Females Excelling More in Mathematics Engineering and Science (FEMMES) capstone, participant in Women In Science and Engineering (WISE), participant and former executive board member of Association for Women In Science (AWIS), Michigan DNA Day pharmacogenomics lecture.
Research Interests:
Our lab tests whether phosphorylation of the cardiac contractile apparatus acts as both an accelerator and a brake for pump performance and whether chronic phosphorylation contributes to heart failure. These ideas are tested using mouse models expressing either a phospho-mimetic or –null substitution at specific phosphorylation sites within contractile proteins. Both structural remodeling and functional performance are studied to determine the impact of these substitutions. Recent work led to a focus on sarcomere- mitochondrial communication and the contribution mitochondrial reactive oxygen species to the development and progression of heart failure caused by a phospho-mimetic substitution in a molecular switch contractile protein. The rationale for this idea is that a critical component of the cardiac contractile apparatus, myosin, uses the majority of mitochondria-derived ATP to drive cardiac pump function. Intuitively, then, impairments in mitochondrial function and subsequent output of reactive oxygen species may play a role in development and progression of heart failure. Indeed, alterations in mitochondrial function (specifically overproduction of reactive oxygen species) are linked to many cardiovascular diseases, including heart failure. Our lab aims to develop a clear understanding of how changes in a sarcomeric protein can trigger changes in mitochondrial redox to potentially cause heart failure.
Mentor:
Xiaoxia “Nina” Lin
Year:
2012
Undergraduate Institution:
University of Oregon
Honors:
CMB NIH training grant, Rackham doctoral pre-candidate research grant, Keystone Synthetic Biology poster presentation, Rackham travel grant, Rackham doctoral Candidate research grant
Service:
CMB newsletter committee, CMB short course committee, UM Medical School Summer science academy, CMB program committee
Teaching Experience:
Tutor for Human genetics HG451 and for Cell Biology CDB530. Graduate Student Instructor for Cell Biology CDB530 and Molecular Biology MCDB427
Research Interests:
Biological engineering for sustainable energy and industrial applications

 

Ron Siebenaler
Mentor:
Arul Chinnaiyan
Year:
2015
Undergraduate Institution:
The Ohio State University
Honors:
American Society of Clinical Oncology Interest Group Grant (2015-2016); Barry M. Goldwater Excellence in Education Program Scholar (2012)
Service:
2016-17 CMB Short Course Committee, University of Michigan Medical School Student Run Free Clinic Volunteer, MSTP Ethics Committee, University of Michigan Medical School Admissions Ambassador, Oncology Interest Group President, Victor Vaughan Society Co-Chair, University of Michigan Medical Journal Reviewer
Research Interests:

Growth factor regulation of AGO2 and RAS in cancer biology.

Mentor:
JoAnn Sekiguchi
Year:
2012
Undergraduate Institution:
Gettysburg College
Honors:
NSF Graduate Research Fellowship, Rackham Graduate Student Research Grant (Precandidate), CMB Training Grant, Benard Maas Fellowship
Service:
FEMMES, Science Olympiad Event Supervisor, CMB Short Course Committee and Website Committee
Teaching Experience:
MCDB 427 – Molecular Biology (Winter 2016)
Research Interests:
Roles of a DNA nuclease in the response to replication stress

 

Mentor:
Deneen Wellik
Year:
2014
Undergraduate Institution:
The University of Michigan
Honors:
CMB Warner Lambert fellowship, Tissue Engineering and Regenerative Medicine training grant, Rackham Pre-Candidate grant, Poster presentation at the 2015 Midwest Society of Developmental Biology meeting
Service:
CMB Summer Journal Club chair
Teaching Experience:
2016 Summer mouse course teaching assistant at Cold Spring Harbor Laboratories
Research Interests:

Defining the role of Hox11 in multipotent mesenchymal stromal cells (MSCs) in the limb

 

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