Studying the intersection between cancer metabolism and epigenetics in brain tumors. Specifically, we evaluate the effects of altered metabolism on histone and DNA methylation in brain tumors.
Initiation and progression of pancreatic cancer with a focus on signaling pathways
Utilizing a chemical-gentic approach to engineer inhibitable kinesin motor proteins s a strategy to elucidate their fundamental properties in cells
Elucidating the role of the Human Endogenous Retrovirus (HML-2) accessory protein Np9 in diverse human malignancies
Structure and function of centromere and kinetochore proteins
I am interested in developing spatial and temporally resolved proteomic techniques to study clathrin-mediated endocytosis.
Studying the role of the immune system in colon cancer development.
Interested in chromatin structure, DNA topology, DNA looping, and the physical mechanisms governing transcriptional regulation. My research is focused on developing molecular methods for the detection and mapping of G-quadruplexes in vivo.
Asymmetric stem cell division and nonrandom sister chromatid segregation in Drosophila melanogaster
Mechanisms of Neurodegeneration in C9orf72-linked ALS and FTD
I am studying factors that may be regulating selective oncogenic Notch1 signaling in T-cell Acute Lymphoblastic Leukemia, using biochemical and in vivo studies.
Elucidating the mechanism of RAN translation in neurodegenerative diseases
Uncovering and characterizing novel chemical and genetic modifiers of the coagulation cascade
Characterization of the evolutionary conserved E3 ubiquitin ligase complex, the GID Complex, and its role in membrane trafficking of plasma membrane proteins during glucose starvation.
Uncovering biophysical rules governing non-coding RNA mediated regulation of translation, focusing on miRNA degradation pathways
I am interested in synthetic biology research which investigates fundamental biological mechanisms in order to engineer innovative systems of novel function for biotechnology applications.
How do genes and environment interact to control longevity and healthy aging? Specifically, I am characterizing a carboxylesterase family member that promotes increased longevity in nematode models of low insulin signaling and high DAF-16/FOXO transcription factor activity.
Asymmetric stem cell division
Investigating the role of ASXL3 in Polycomb repression and characterizing the transcriptional plasticity required for neural differentiation
Alyssa is broadly interested in the cellular mechanisms governing mammalian tissue development, disease, and repair.
Elucidating the downstream mechanisms by which FMOs, flavin-containing monooxygenases, extend lifespan in C. elegans and mice.
Examining the therapeutic potential of chaperone machinery in neurodegenerative diseases
Transciptome analysis of cancers
Understanding the role of stromal cells in alloimmunity and other immune responses.
Kras mediated pancreatic carcinogenesis
Neuronal growth factors guide the development and maintenance of the nervous system
Growth factor regulation of AGO2 and RAS in cancer biology.
Defining the role of Hox11 in multipotent mesenchymal stromal cells (MSCs) in the limb
The regulation of Myosin V attachment to cargoes
Currently working on the mechanisms of muscle membrane wound repair mediated by dysferlin and the muscle cytoskeleton.
The regulation of myosin V attachment to cargoes
Regulation of neuron morphological development: Determining the upstream signaling mechanisms of the Krüppel-like transcription factor Dar1 in Drosophila