Utilizing a chemical-gentic approach to engineer inhibitable kinesin motor proteins s a strategy to elucidate their fundamental properties in cells
Elucidating the role of the Human Endogenous Retrovirus (HML-2) accessory protein Np9 in diverse human malignancies
Structure and function of centromere and kinetochore proteins
I study the biosynthetic trafficking of G-protein-coupled receptors (GPCRs). GPCR localization to the the cell surface is critical for functional coupling to both extracellular agonists and G-protein effectors on the plasma membrane. Despite the functional importance of GPCR localization to the plasma membrane, relatively little is known about the biosynthetic trafficking of these receptors to the cell surface. I would like to understand how the trafficking of these receptors to the cell surface is regulated and how we can target receptors to the surface to increase signaling.
I am interested in developing spatial and temporally resolved proteomic techniques to study clathrin-mediated endocytosis.
Studying the role of the immune system in colon cancer development.
Asymmetric stem cell division and nonrandom sister chromatid segregation in Drosophila melanogaster
Mechanisms of Neurodegeneration in C9orf72-linked ALS and FTD
I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
I am studying factors that may be regulating selective oncogenic Notch1 signaling in T-cell Acute Lymphoblastic Leukemia, using biochemical and in vivo studies.
Elucidating the mechanism of RAN translation in neurodegenerative diseases
Uncovering and characterizing novel chemical and genetic modifiers of the coagulation cascade
Uncovering biophysical rules governing non-coding RNA mediated regulation of translation, focusing on miRNA degradation pathways
Studying the mechanism of nuclear pore complex formation in neurons and the role of torsinA with regards to nuclear pore biology
I am interested in synthetic biology research which investigates fundamental biological mechanisms in order to engineer innovative systems of novel function for biotechnology applications.
How do genes and environment interact to control longevity and healthy aging? Specifically, I am characterizing a carboxylesterase family member that promotes increased longevity in nematode models of low insulin signaling and high DAF-16/FOXO transcription factor activity.
Identify and examine the homeostatic regulation of mu-opioid receptor recycling and study its regulatory signaling pathway. Study and identify the cellular molecules required for opioid receptor trafficking and signaling in response to various neuropeptides.
I am pursuing my thesis in the Dauer lab. I plan to study the role of cholinergic interneuron dysfunction in movement disorders such as Parkinson’s disease and DYT1 dystonia. These studies include behavioral and molecular experiments involve conditional knock-outs of Tor1A, the gene mutated in DYT1 dystonia, as well as knock-ins of the mutated form of Tor1A found in patients. I am also studying the roles and relationship between Tor1A and Tor1B, a neighboring and highly similar gene. These experiments involve various combinations of Tor1A and Tor1B knock-outs and will shed light on the...
Investigating the function of paternally-inherited histones during early embryogenesis.
Investigating the role of ASXL3 in Polycomb repression and characterizing the transcriptional plasticity required for neural differentiation
Alyssa is broadly interested in the cellular mechanisms governing mammalian tissue development, disease, and repair.
Elucidating the downstream mechanisms by which FMOs, flavin-containing monooxygenases, extend lifespan in C. elegans and mice.
Examining the therapeutic potential of chaperone machinery in neurodegenerative diseases
Understanding the role of stromal cells in alloimmunity and other immune responses.
Growth factor regulation of AGO2 and RAS in cancer biology.
Defining the role of Hox11 in multipotent mesenchymal stromal cells (MSCs) in the limb
The regulation of Myosin V attachment to cargoes
Currently working on the mechanisms of muscle membrane wound repair mediated by dysferlin and the muscle cytoskeleton.
Mitochondria are mobile organelles and exist in dynamic networks that constantly undergo mitochondrial fission and fusion. Disorders in mitochondrial dynamics have been shown to be involved in various diseases such as neurodegenerative, neoplastic, endocrine and cardiovascular diseases. Not much is known about how the ER protein quality control system can regulate mitochondrial function. Since brown adipose tissue (BAT) contains an abundance of mitochondria, it is a good model to study how ER-mitochondrial crosstalk affects mitochondrial function. Both Sel1L and Hrd1 together are vital...