I work in a beta-cell biology and diabetes lab. We are investigating how a selective form of autophagy, mitophagy, contributes to beta-cell bioenergetics and insulin secretion.
I am studying factors that may be regulating selective oncogenic Notch1 signaling in T-cell Acute Lymphoblastic Leukemia, using biochemical and in vivo studies.
Elucidating the mechanism of RAN translation in neurodegenerative diseases
Uncovering and characterizing novel chemical and genetic modifiers of the coagulation cascade