Leadership

a b c d e f g h i j k l m n o p q r s t u v w x y z All
(Includes Name, Title, Research Interests)
Cell and Developmental Biology
Associate Director of CMB
Research Interests:

Research in the Allen Lab is broadly focused on understanding the mechanisms of growth factor and morphogen signaling in development and disease. Specifically, we study the regulation of Hedgehog signaling during embryonic and postnatal development, as well as adult tissue homeostasis, repair and regeneration. Our research employs a wide range of approaches, including mouse genetics, chicken in ovo electroporations, biochemistry, and cell biology. The long-term goal of this work is to apply insights gained from the study of HH signaling in normal contexts to the treatment of a broad...

Biological Chemistry
Associate Director of CMB
Research Interests:

My laboratory studies protein localization and processing in the eukaryotic secretory pathway.

Cell and Developmental Biology
Associate Director of CMB
Research Interests:
Our laboratory investigates the formation and progression of pancreatic cancer, one of the most lethal human malignancies. We study embryonic signaling pathways, such as Hedgehog and Wnt, which are activated during pancreatic carcinogenesis. The Hedgehog signaling pathway is not active in healthy adult pancreas. However, in pre-malignant lesions and in invasive pancreatic cancer Hedgehog signaling becomes activated via overexpression of one of the ligands, Sonic Hedgehog (Shh).

 

Lauren Perl
CMB Program Administrator
Manoj Puthenveedu
Director of CMB
Pharmacology, Associate Professor
Accepting New Students?
Yes
Research Interests:

The Puthenveedu lab studies how receptor signaling pathways are organized in the cell, focusing on GPCRs relevant to drug addiction. We investigate the exciting new idea that signaling is specified not just by the drug/receptor pair, but also by where in the cell the receptors are located. We use innovative microscopy and molecular genetic techniques to directly track receptor trafficking and function in real time in living cells. The long-term goal is to identify factors that will allow us to actively relocate receptors to specific sites in the cell to fine-tune signaling.